Saturday, May 23, 2020

3 pasos para renovar sin entrevista la visa de turista

La renovacià ³n de la visa de turista para Estados Unidos puede hacerse siguiendo un trà ¡mite rà ¡pido y sencillo siempre que se realice dentro de plazo. En este artà ­culo se informa sobre quià ©nes no necesitan la visa de turista y por lo tanto no precisan renovarla. Tambià ©n cuà ¡ndo se tiene que renovar, si se tiene una, cà ³mo es el proceso, quà © 3 decisiones puede tomar el oficial consular y quà © no se debe hacer porque pone en peligro la visa y/o su renovacià ³n. Con esta informacià ³n serà ¡ fà ¡cil obtener la renovacià ³n del visado. Quià ©nes no necesitan una visa de turista para ingresar a Estados Unidos Es importante saber que las personas extranjeras que desean viajara a Estados Unidos como turistas o para recibir tratamiento mà ©dico necesitan de una visa B2 o la combinacià ³n de una B1/B2 de turista/negocios, si bien existen importantes excepciones: Mexicanos y extranjeros residentes en Mà ©xico que viven junto a la frontera pueden solicitar una tarjeta de cruce, tambià ©n conocida como visa là ¡ser. Pero sà ³lo sirve para un tiempo mà ¡s limitado que la visa de turista y tambià ©n està ¡ restringida a ingresos terrestres y no permite adentrarse ilimitadamente en territorio de los Estados Unidos.CanadiensesCiudadanos de 38 paà ­ses parte del Programa de Exencià ³n de Visas.   Entre esos 38 paà ­ses se encuentran, entre otros, Espaà ±a, Chile, Italia y Portugal, lo cual puede ser de interà ©s para muchos latinoamericanos que cuentan con doble nacionalidad, siendo una de ellas la de un paà ­s incluido ese ese Programa de Exencià ³n de Visas. Cuà ¡ndo es necesario renovar la visa de turista Si ya se tiene una visa de turista, conocida en algunos paà ­ses como de paseo o de placer, à ©sta tiene una vigencia limitada. Puede dejar de ser và ¡lida porque se aprueba por un nà ºmero limitado de ingresos y estos ya se han agotado o porque ya ha llegado su fecha de expiracià ³n (tambià ©n conocida como de vencimiento). En cualquiera de estos casos es necesario renovar la visa si se quiere viajar de nuevo a los Estados Unidos. El proceso es muy similar a los de peticià ³n por primera vez, pero con dos importantes novedades: el porcentaje de aprobacià ³n es mucho mà ¡s alto en las renovacionesen  algunos  casos no es necesaria la entrevista en el consulado. Estas circunstancias se han endurecido desde que el presidente Donald Trump entrà ³ en la Casa Blanca. 3 trà ¡mites para la renovacià ³n de la visa de turista americana Deben seguirse los siguientes pasos: En primer lugar, completar en là ­nea el documento DS-160.  La opcià ³n que aplica es la de visa renewal. Aunque el formulario està ¡ en inglà ©s, es posible ver una traduccià ³n al espaà ±ol colocando el cursor encima del texto que se quiere traducir. En segundo lugar, pagar la cuota correspondiente. El procedimiento de pago tiene variaciones de paà ­s a paà ­s por lo que se debe seguir las instrucciones del DS-160. Esta tarifa nunca se regresa, aunque la visa no sea aprobada. En tercer lugar, si es necesario cerrar una cita para la entrevista en la oficina consular, seguir el procedimiento. Si no es obligatorio, proceder a entregar la documentacià ³n como se seà ±ala en el formulario de internet.   Casos de exencià ³n de la entrevista para renovar la visa de turista americana La entrevista en el consulado o embajada es uno de los trà ¡mites que mà ¡s disgusta a los solicitantes de las visas de turista. Una de las razones es porque la necesidad de presentarse en el edificio consular obliga a dedicar buena parte de una maà ±ana a ese trà ¡mite o incluso mà ¡s, si hay que desplazarse a otra ciudad. Pero ademà ¡s, hay el factor subjetivo de los nervios. No todas las persona se ponen nerviosas, pero muchas sà ­, por no saber quà © le van a preguntar, por temor a dar una respuesta equivocada, etc. Por todo ello, la posibilidad de no tener que acudir a la entrevista es festejado por muchos solicitantes de la renovacià ³n de la visa. El  Programa de Exencià ³n de la Entrevista, conocido por sus siglas en inglà ©s de  IWP, que establecià ³ paulatinamente el gobierno del presidente Barack Obama permità ­a muchos casos de renovacià ³n sin necesidad de entrevista. Sin embargo, el  Ã‚  Donald Trump ha anulado esa waiver en muchos casos. Actualmente, estos son los lineamientos para no tener que presentarse a la entrevista durante la tramitacià ³n de la visa de turista americana: Nià ±os de 6 aà ±os o menoresPersonas mayores de 80 aà ±osPersonas cuya visa de turista haya expirado hace menos de 12 meses y que nunca hayan tenido problemas en las aduanas de EE.UU., nunca hayan sido detenidas y a las que nunca se les haya negado o anulado una visa americana. En todos los casos, las embajadas y consulados de Estados Unidos pueden decidir unilateralmente que un solicitante debe presentarse a la entrevista aà ºn cuando entre dentro de las excepciones que en teorà ­a permitirà ­an no tener que cumplir con ese propà ³sito. Quà © puede suceder durante el proceso de  renovacià ³n de la visa El oficial consular puede decidir: aprobar la visadeclarar un procedimiento administrativo, es decir, ni aprobacià ³n ni negacià ³nNegar la visa. ​ Las posibilidades de que esto suceda son pequeà ±as, ya que en los casos de renovacià ³n se produce menos de un dos por ciento de rechazo de entre todas las solicitudes. Pero sà ­ que es una posibilidad real. No obstante, es mucho menor a lo que sucede cuando se solicita por primera vez, donde el rechazo en general supera el 20 por ciento de las peticiones, si bien hay grandes diferencias segà ºn el consulado. Las causas por las que se produce un rechazo caen bà ¡sicamente dentro de dos grandes categorà ­as, causas que convierten a una persona en inelegible para la visa de turista y las que la convierten en inadmisible para ingresar a los Estados Unidos.   Si el problema se origina por una de estas à ºltimas causas, es aconsejable asesorarse con un abogado de inmigracià ³n especialista en waivers para analizar si es conveniente solicitar uno. A esto tambià ©n se le conoce como perdones o permisos. Quà © puede poner en peligro conservar la visa de turista Para evitar problemas muy desagradables e incluso sufrir la cancelacià ³n de la visa es conveniente saber la respuesta correcta a estas dos preguntas:  ¿es conveniente quedarse en EEUU el mà ¡ximo tiempo permitido? En este punto es de extrema importancia conocer las consecuencias, ya que desde el punto de vista migratorio son graves. Ademà ¡s, es importante saber  con quà © frecuencia se puede regresar  a Estados Unidos como turista ya que la mayorà ­a de los viajeros no son conscientes de que el ingreso a EE.UU. les puede ser negado por un oficial migratorio aunque, en teorà ­a, està ¡n movià ©ndose dentro de los parà ¡metros que marca la ley. Para mayor informacià ³n sobre cà ³mo obtener y conservar la visa, se recomienda tomar este  este quiz, trivial o test sobre visas. Este artà ­culo tiene una finalidad informativa. No es asesorà ­a legal para ningà ºn caso en particular.

Monday, May 18, 2020

Fate In Gabriel Garca M�rquezs Chronicle Of A Death...

For millennia, an idea of fate has driven the actions of countless societies and numerous individuals. Determinism, or a belief in the power of fate to preordain what will happen, has been and continues to be the predominant default behavior for many. Discounting free will, the people who adhere to it (or merely default to it) often rely on the idea of fate to absolve them of duty otherwise required of civility. This is exemplified in Gabriel Garcà ­a Mà ¡rquez’s famous novella Chronicle of a Death Foretold, in which most of the characters rely on determinism as justification for their actions—without conscious belief in the power of fate. However, Mà ¡rquez himself rejects common, unconscious, and default belief, instead positing that chance†¦show more content†¦As a matter of fact, this entire scene is repeated later in the plot while the twins retrieve new knives. Not once was the collective faith in determinism tested, but twice. Such a repeat serves to satirize this conspicuous lack of action. Separately, Clotilde Armenta wants someone to act to save Santiago, as long as that someone is not herself. She implores Colonel Aponte to prevent the twins from attempting the murder, â€Å"to spare those poor boys from the terrible duty that’s befallen them† (Mà ¡rquez 57). Despite this, she doesn’t see the irony in failing to act herself, and never ends up directly working to stop them. Armenta later warns Santiago through a note she passes to a beggar (58), instead of knocking on his door and speaking to him directly, or talking the twins out of their supposed duty. An easy solution exists in more decisive action, considering Armenta’s physical and temporal proximity to both the killers and Santiago. However, she seems to simply not care enough to try to prevent the murder herself. This construction of apathy among the townspeople by Mà ¡rquez serves to show the irony in an unconscious belief in determinism. By assuming that Santiago will somehow fi nd out (or that he already knows) about his impending death, everyone in the town ends up allowing his death to occur. While satirizing the unreasonability of Santiago’s death, Mà ¡rquez casts a critical eye

Tuesday, May 12, 2020

Drug And Alcohol Abuse Essay - 994 Words

If I were an advisor to the Governor of Missouri, the issue I would encourage him to address is the manufacture of drugs and the use of drugs and alcohol throughout our state. The advice I would give him is to impose stiffer penalties for those who manufacture drugs and focus on prevention, and, most importantly, rehabilitation, of those who abuse alcohol or drugs.According to the Missouri Department of Mental Health, alcohol and drug abuse affects more than 259,000 Missourians and another 800,000 who are family members of substance abusers. That is roughly 20% of Missourians who are affected. Intoxication by the means of drugs and alcohol contribute to a great percentage of deaths statewide from burns, fires, homicides, assaults,†¦show more content†¦Once in college, these students get drug-tested every semester and the scholarship is renewed every semester they are drug-free. This is by far the best solution I have seen to keep our youth off of drugs and there should be mo re scholarships like it.For those who are arrested for abusing drugs and/ or alcohol, there should be mandatory rehabilitation if the party involved is convicted. A jail term, fine and/ or community service should be mandated as well, but without rehabilitation, the person convicted will be more likely to continue abusing drugs and/ or alcohol. Drug and/ or alcohol addicts need to feel love and peer support despite their faults in order to make any progress on the road to rehabilitation. Often times, a jail sentence, fine and/ or community service alone causes only resentment and defiance among addicts. These individuals need to be around people who care for them and Alcoholics and Narcotics Anonymous provides these individuals with the support that they need. In order to fully understand drug and alcohol addiction, we must first comprehend the phases of addiction itself. According to a handout given to addicts at the Lester E. Cox Medical Center the first stage of addiction is called the pleasure stage. This stage includes peer pressure, curiosity, attraction, release of inhibitions and relaxation. This is the stage in which usage isShow MoreRelatedDrug Alcohol And Alcohol Abuse Essay980 Words   |  4 PagesDrug and Alcohol Abuse Drug and alcohol abuse is something that is happening more and more often it seems. There are many reason for this happening. First of all, people experiment with drugs and alcohol mainly out of curiosity. Maybe their friends are doing it, they just want to have a good time, or they could be hoping to improve athletic performance. It is common thing at parties and social gatherings for people to feel the need to drink or try drugs. Another reason start to use and abuse drugsRead MoreDrug Abuse And Alcohol Abuse749 Words   |  3 Pagesworking for the State of New Hampshire in particular the Bureau of Drug and Alcohol Services. This is an agency within an agency. The main reason I chose this area is due to two factors: the first one is that drug and alcohol is such a sever addiction that it is almost impossible for the individual to get out of it on their own. The second factor is first-hand experience. I myself have been down the same road as so many others with drug abuse and add iction. I certainly believe that this experience willRead MoreAlcohol and Drug Abuse1722 Words   |  7 PagesAlcohol and Drug Addiction Samara Kitchens COM/156 Instructor: Sunday, May 19, 2013 There was a missing person report across the news today, my co-worker stated. I never paid any attention to it; I went on about my day as if everything was fine. When I arrived at home I had severalRead MoreThe Abuse Of Drugs And Alcohol1365 Words   |  6 PagesThe abuse of drugs and alcohol has been a known issue over past decades. The media paints the picture that alcohol and drug use is fun and the only way to have a good time. While alcohol in moderation is fine, many people find themselves going over board and abusing it. Elicit drugs like cocaine and heroin are highly addictive and have several adverse effects. People find themselves depressed and anxious so they ultimately try to use these drugs to mask the pain instead of getting help for theirRead MoreThe Drug Of Drug And Alcohol Abuse Essay1531 Words   |  7 PagesThe movie Trainspotting is an entertaining look into the dark world of drug and alcohol abuse. Heroin is the drug of choice for the protagonist , but other substances are also consumed throughout the film: heroin, prescription medication, opium, hash, amphetamines, and alcohol are a constant presence in the story. Repeated polysubstance abuse combined with a negative social environment and a weak support structure compounds the problems of Renton, a heroin addicted young adult man living in ScotlandRead MoreThe Abuse Of Drugs And Alcohol1146 Words   |  5 PagesThis paper examines how the abuse of drugs and alcohol can drastically alter the dynamics of the family as a whole. Addiction is a chronic disorder that tears families apart as it destroys the individuals themselves. There is a thin line that family members walk in order to function with an addict daily. The impact that family member have can either be a positive facilitator towards the addicts recovery or the family can become drawn into the addicts world of abuse and addiction. There are variousRead MoreDrug Alcohol And Drug Abuse1773 Words   |  8 Pagesnet - guide - Avoiding Alcohol And Drug Abuse In College College is a time of great personal growth and education, but it is also a time to have a lot of fun. Unfortunately, people often take this fun too far by delving into excessive drug and alcohol abuse. This impacts millions of college students every year in multiple ways, including creating a lifelong addiction, causing educational problems, and even personal injury. However, it is possible to avoid alcohol and drug abuse in college. It takesRead MoreEffects Of Alcohol And Drug Abuse919 Words   |  4 Pagesof Alcohol and Drug Abuse There may be some things that you don t know about the impact of drug and alcohol abuse on friends and family and how your friends and family may react to your choices. Having knowledge about alcohol and drug abuse, preventing toxic relationship with friends, and being informed about the consequences of drug and alcohol abuse can prevent the harmful use or consumption of drugs and alcohol. First and foremost, having knowledgeable information on the impact drugs andRead MoreAdolescent Drug Abuse And Alcohol1426 Words   |  6 Pages1 RUNNING HEAD: Alcohol and Drug Abuse Adolescent Drug Abuse and Alcohol Nyria Madison Liberty University Coun 620 Abstract Around the world we are finding that most adolescent are experiencing drugs and alcohol. This has been a huge issue for years. This has become a trend in society as of today. This paper will discuss the perspective of adolescent alcohol and drugs. This paper will also identify and inform you on the common predictors of adolescentRead MoreThe Problem Of Drugs And Alcohol Abuse765 Words   |  4 PagesIntroduction My chosen contemporary social problem is drugs and alcohol abuse. It goes without saying that drugs and alcohol abuse is one of the most significant social problems not only in the United States but also around the world. As a matter of facts, drugs and alcohol abuse is a problem with innumerable effects both on the body and mind of a person. Many times, these adverse impacts affect the families, friends, and acquaintances of the addict whereby, for instance, the latter may lose their

Wednesday, May 6, 2020

Should College Athletes Get Paid Essay - 1184 Words

Today there are a lot of big questions in this world about one specific topic. The answer is even more important than maybe half of the questions, but there isn’t a correct answer to this question. It’s a belief and what you think question. This question is paid attention to by a lot of high school student athletes, but not only high school athletes but current college athletes. This question is maybe one of the reasons why a lot of college athletes leave college and go to the pros after just one year in college. The question is â€Å"should college athletes get paid?† A lot of people reading this right now have different opinions and views on this, and the question itself just pops. Well first I think college athletes getting paid would†¦show more content†¦Especially the big main sports such as football and basketball. The school has a lot of radio, TV, and newspaper deals that also bring money to them. You have to think about the people who canâ€℠¢t always watch the game, they can hear it. Not only do they have those contracts, but you got to remember when the actual games start and there at the big stadium or dome. The revenue for one game is over 10,000 to 20,000 people just for one game. They have prices for food, beverages, stuffed dolls, programs, and souvenir, that a lot of that 10-20,000 buy at all the games. This is very messed up because most of the souvenirs are the current player’s jersey with their number on it, but the jersey doesn’t have their name on the back of it, just their number. The jersey makes the sale with or without the players name on it and none of the players get a cut of any type of money. So the players just worked their buts off since JFL just to get to college and get not even a couple dollars. â€Å"Don’t get me wrong, it’s an unbelievable organization – but in some way they’re taking advantage of college athletes that sign their name into a certain school.† â€Å"When I was (at Alabama) in ’09, I think revenue when we won the national championship that year was like $62 million. And when we won it in New Orleans (in 2011), it was like $78 million. Then when we beat (Notre Dame in 2012), it was like $92 million.† (Mitrosilis) Every kid who everShow MoreRelatedShould College Athletes Get Paid?1338 Words   |  6 Pages13,2016 Should College Athletes Get Paid College sports are something that everyone has thought about, and many question whether or not they should get paid for it. Many Americans question whether or not it is right or wrong to pay college athletes to play sports. College athletes deal with a lot, from balancing classes to long practices in the evening. College is supposed to be a time when some individual figures out what he or she wants to do, but not for athletes. Most college athletes go to collegeRead MoreShould College Athletes Get Paid?853 Words   |  4 PagesShould College Athletes Really Get Paid? The question whether â€Å"If college athletes should get paid or not?† has been debated for many years. The debate is brought up every year during the NCAA men’s basketball, March Madness competition, and starts again when football season begins. College athletes do provide entertainment for sports fans, but all the benefits that they do receive should limit them from being paid. The benefits student athletes obtain is free tuition, health coverage, and an openedRead MoreShould College Athletes Get Paid?1742 Words   |  7 PagesShould College Athletes Get Paid? Should college athletes be paid? This has been a controversial topic ever since college sports started. Many people argue that they should. Many people argue that they should not. College athletes should get paid because they work extremely hard playing their sport. The people that say they should be paid argue that the amount of time athletes dedicate is equivalent to a full-time job, and maybe even more. The people that say they should not get paid argue that collegeRead MoreShould College Athletes Get Paid?1196 Words   |  5 Pagesa huge debate on whether or not college athletes should be paid. For years now college athletes have gone out and performed on national television, working hard to make it to the next level. They have given it there all, and not only that, the athletes bring in about $11 billion in annual revenue from college sports. Now days, sports is a business, and college sports are the same. Division 1 college sports provide a lot of income for the universities. Many athletes receive scholarships and a littleRead MoreShould College Athletes Get Paid?999 Words   |  4 PagesPlaying a college sport today is not just fun anymore. College sports are becoming a business and the athletes are the workers. The money some sports programs make from ticket sales, concessions, and media exposure is tremendous. Students playing sports are the ones people pay money to watch, so do the colleges not pay the athletes since they are the ones that bring in the money. They train year around to make themselves and their team better but what do they see for all of this hard work and dedicationRead MoreShould College Athletes Get Paid1503 Words   |  7 PagesTrey P. Ragas Mr. Derm English 4 21 April 2016 Should College Athletes Get Paid In the course of recent decades, school sports have increased enormous ubiquity over the United States. Whether it be football, ball, or hockey, since the time that the turn of the century, intercollegiate games have acquired an overflow of income to their separate Universities, and in addition expanding the fame of the College s notoriety. For instance, in a study directed by the Orlando Sentinel, it wasRead MoreShould College Athletes Get Paid?793 Words   |  4 Pagesscholarships given to college athletes are not sufficient enough to sustain them throughout the year, which is why I believe they should get paid and receive benefits. Student athletes, especially football and basketball players, play a major role in generating revenue for schools, businesses, coaches and the players do not see a penny. College athletes often do not have money in their pockets for extra food, clothes, housing and extracurricular activities. They also can potentially get dropped from theirR ead MoreShould College Athletes Get Paid?942 Words   |  4 Pagespopularity of college basketball and football keeps increasing each sport season. These sports bring in millions of dollars towards there universities every year. Are these universities ripping these athletes off? Should college athletes get paid? They risk their bodies to bring money for their school. While college athletics bring money toward their schools, paying athletes would change the main role of the university which is to get an education. Athletes forget that they are student-athletes. It seemsRead MoreCollege Athletes Should Get Paid1749 Words   |  7 PagesCollege athletes should get paid Imagine working day in and day out every day to meet academic standards and trying to keep your level of play competitive up. That’s what college athletes go through every day. College athletes have gained immense popularity over the past few decades. The NCAA took advantage of this and made billions of dollars off college athletics According to USA Today, the NCAA last season the NCAA made over $845 Billion dollars in revenue from games, merchandise sales, televisionRead MoreShould College Athletes Get Paid?2214 Words   |  9 Pages Jasmine Arenas College Athletics: Should college athletes get paid? Over the years, we have seen colleges and universities benefit extremely from their sports programs. Every year a great team brings tremendous amounts of revenue for their university. However, as these universities increase their finances, their athletes are falling behind financially, academically, socially and personally creating a huge burden upon them. College/university athletes practically work overtime for their academic

American Identity Prior to the Revolutionary War Free Essays

Early American Identity Robert Zimmermann Madrigal During the time prior to the revolutionary war, there was a mixed sense of identity within the colonies. Some of the colonists saw themselves as English citizens, while others saw themselves as Americans and wanted a free, self governed nation. The first actuall sign of American identity was in 1754 when Benjamin Franklin proposed the Albany plan, as represented in Doc. We will write a custom essay sample on American Identity Prior to the Revolutionary War or any similar topic only for you Order Now A. Even though his proposition was denied it still showed that people were starting to take the idea of being â€Å"American† into account. In Document B. Edmund Burke shows his resentment of how American is being governed. Is there a single trait of resemblance between those few towns, and a great and growing people spread over a vast quarter of the globe, separated from us by a mighty ocean. † He says that he doesn’t believe that the colonies should be ruled by a nation that is so different and so far away. â€Å"The eternal barriers of nature forbid that the colonies should be blended or coalesce into the mass†¦ of this Kingdom. † He again states that the colonies should not be ruled by Great Britain. After the French and Indian war England was in a great amount of debt, so they started to impose taxes of the colonies. The people living in the colonies had lived in the colonies their whole lives and had never been taxed by the government before, so they were very unhappy about them. The people of the colonies protested against all of the acts that the British government had set. From the years of 1763 to 1774 the British government proposed a series of acts that imposed taxes and regulations on the people of the colonies. The proclamation of 1763 being the first of them, prevented the colonists from moving into territory past the Appalachien mountains. This was the begining of an era of protest and unhappiness. In Document C. Richard Henry Lee talks about how the colonies are all working together to fight for their liberties against â€Å"every power on Earth that may attempt to take them away†. In Document D. The Declaration for the causes of taking up arms says â€Å"We will, in defiance of every hazard, with unabating firmness and perserverance, employ for the preservation of our liberties; being with one mind resolved to die free men, rather than live like slaves. This is saying that they wanted their freedom from oppression. In 1774 The British government issued a series of laws that later came to be known as the â€Å"Intoerable Acts†. These most impacting thing these acts did was closing the port of Boston. This only deepened colonial hostility. The other colonies provided food and money to Massachusets. Document G. is a list of the vast amount of provisions provided to the Boston relief effort. In Document H. Hector Crevecoeur reffers to America as a melting pot, where the ancestors of people are forgoten and they become new men and women. All of these documents provide the facts needed to infer that there was a great sense of American Identity in the Americas prior the the Revolution. How to cite American Identity Prior to the Revolutionary War, Essay examples

HIV Vaccine Progress and Challenges

Question: Describe about the HIV Vaccine Progress and Challenges. Answer: Human immunodeficiency virus is a deadly virus that has shaken the world of scientists since the time it was discovered among different citizens. This virus affects the immune system in a way that its interferes with the immune system create situations where other infections like tuberculosis, influenza and other opportunistic infections can easily invade the human being. The immunity system loses its capability to fight with the new infections due to the interruption in its activity by the already present HIV virus. Over decades, it has resulted in loss of huge number of lives and scientists have yet not been able to come out with effective vaccine against it. Various researches all over the world are still being conducted to make the world a safe place from this virus. The essay would therefore contain the various challenge and progresses in the field of the research of HIV vaccine in the present generation. It has been noted that over the decades, different medications have been proposed which has helped in stabilisation of the symptoms of aids but has not cured or protected an individual from such viruses (Kwong Mascola, 2012). Vaccines have therefore become necessary to protect an individual from acquiring the infection so that the concern of curing or treatment does not arise. The main challenge faced by the scientists while preparing the vaccine for HIV is that the proteins present on the viral envelope are quite different and do not match with the other viruses whose vaccine has been created. Therefore, preparations of primers that would match the antibodies occurring from adaptive immunity have not become successful. To explain clearly, a person suffering from HIV infection would develop antibodies against it and mimicking these antibodies to create a vaccine as a protective measure for normal healthy individuals to protect them from HIV, has not been possible yet. The victims ha ve not survived long enough after HIV infection to make this technique successful (Ensoli et al., 2014). Another challenge often faced by the scientists is that killed HIV virus becomes unresponsive and fail to act as antigen when administerd into an animal model to produce antibodies against it. Other virus when killed but administered into a healthy being evokes response and thereby helps in collecting antibodies from this individual to produce mimicked antibodies and use it as vaccine to other individuals. This is not possible by HIV viruses. Moreover live viruses cannot also be used to produce antibodies due to ethical issues and regulations. Therefore scientists often face challenges in creating a proper vaccine (Koff, 2012). There is another challenge faced by the scientists while preparing vaccine is the evolving nature of the HIV virus. HIV virus undergoes high rate of mutation within the body of infected individual. They are not affected the pressure imposed on them by the immune system of the body. They respond with high efficiency to the various selective pressure of the immune system and alters themselves through various mutation to remain unaffected by the both antibody mediated immunity and cellular immunity (Ensoli et al., 2014). Due to this evolving nature of the viruses, often scientists have found it difficult to cope up with the researches required to form an effective vaccine. Another challenge that is faced by the scientists during the preparation of the vaccine is the huge amount of genetic variance and genetic divergence that reside in the various isolates of the HIV virus. The ability of the HIV virus to be integrated into the DNA of the host and the error prone nature of the HIV reverse transcriptase lead to a wide genetic diversity in the HIV virus over time (Haynes McElrath, 2013). HIV virus is found to possess a large number of clades as well as subtypes. Therefore, creation of an effective vaccine would require the vaccine to evoke an immune response that would cover all the subtypes and clades of HIV. This implies that a vaccine of a broad spectrum is required to prevent a huge number of subtypes to cause infection. Therefore, efficacy of the vaccines produced till date has shown little success (Esparza, 2013). Therefore, the preparation of a vaccine depending upon the antibody response of an individual is not taken into account by the scientists. Rather, they have accepted the development of vaccine that would solely aim at the response evoked by the cytotoxic T lymphocytes. Broadly neutralizing antibodies called the bNAbs are mainly researched which are produced when scientists focus on the envelop based vaccines. These antibodies usually act by directly binding to the envelope protein of the HIV and prevent their further activities. However, they are very difficult to produce as it requires high somatic hyper mutation which is a prolonged process that ultimately fails to stop the rapid co evolution of the virus. High degree of sequence variability in the envelope gene in the virus makes this process a lengthy one (Martin Siliciano, 2016). After the 2009 trial of the RV144 phase 3 trial in Thailand, two international teams had been working extensively to increase the efficacy level of 31.2% found in the trial in Thailand. In 2012, researches conducted have shown that IgG antibodies to HIV-1 Env V1-V2 have shown that it can correlate inversely with infection risk and thereby supports the fact that antibodies, which bind to the V1V2 Env region, can take active part in the prevention of the enzyme. To carry forward with the research, four more V2 monoclonal antibodies were selected from the already established RvV144 vaccine but it was found that they could not neutralized the HIV-1 CRF01_AE tier 2 viruses. However, they were easily binding with the surface of CRF01_AE tier 2 virus-infected CD4+ T cells. This proved that they were efficient enough to cause antibody dependent cellular toxicity (Kim,Excler Michael, 2015). Just like the Anti-V1V2 BnAbs RV144 V2 mAbs, RV144 V2 mAbs were also found to bind the same V2 Env reg ion. A point that was found in the studies with RV144 V1 mAbs is that like Anti-V1V2 BnAbs they cannot bind glycans and also the V2 region where the mAbs can bind shows variation in their conformation. This is mainly due to the fact that Anti-V1V2 BnAbs have a beta strand but the mAbs have an alpha helix. However, it has raised the vaccine induced immune to near about 50 % showing a progress in the field of HIV vaccine. This has raised expectations that V2-antibody-mediated ADCC of infected CD4+ T cells can thereby act as a potential mechanism of protection against HIV. However, an aspect that has been found here is that in presence of the low tier anti Env IgA antibodies, the antibody-dependent cellular cytotoxicity (ADCC) shows inverse correlation with infection risk in RV144 which thereby shows that anti-Env IgA antibodies reduces the protective effects of IgG antibodies and activities of CD4+ T cell helper responses (Streeck et al., 2013). To simplify, it states that IgA antibodies in serum can inturn block the ADCC activity of IgG anti-Env antibodies. These researches are still going on and has been planned to be conducted in South Africa on non human primates with the similar principles of RV144 but with a different HIV subtype this time (Watkins, 2012). A further progress was made when it was tested in South Africa that gave more insight into the modern attempts to develop a vaccination against HIV. Based on the RV144 vaccine model, the P5 vaccine regimen was prepared by the scientist, which used the application of the ALVAC prime as well as resulted in protein boost. This regimen was examined on the HIV Vaccine Trials Network 100 phase 1/2a study in South Africa. Depending upon the this regimen, another study was proposed to be set in the late 2016 with an aim to improve the results of RV144 vaccine (Russell Marovich, 2016) An important progress was also found in the preparation of mosaic vaccines against HIV. This research was conducted to handle the overcoming of HIV-1 virus diversity. The technique was mainly based on the induction criteria of the cross reactive Tcell responses to that of the HIV-1 virus. The vaccines were designed in silico and are known as the conserved and mosaic vaccines and were constructed with the aim of creating a broad coverage across both the CD4 and CD8 T cells epitopes. These were conducted on Nonhuman primates to prove the efficiency. Phase 1clinical trials began in the year 2014 and are going on to establish a vaccine that can tackle the HIV infection (Haynes et al., 2014). It can be concluded that even in spite of several difficulties and challenges, scientists all over the world have dedicated themselves in the creation of a vaccine that would relieve mankind from the burden of the infection. Scientists have taken out different ways to tackle the genetic divergence of the virus and create a vaccine that would be able to treat the virus and handle the genetic divergence with high efficacy. Due to the high rate of mutation that they can undergo, producing vaccines have become extremely complex (Fauci, Folkers Marston, 2014). However, as the scientists have already reached an efficacy level of 50%, the world can hope a day when the scientists can give us a 100% efficient vaccine that would relieve humankind from this dangerous virus thereby changing the face of the world with this scientific revolution. References: Ensoli, B., Cafaro, A., Monini, P., Marcotullio, S., Ensoli, F. (2014). Challenges in HIV vaccine research for treatment and prevention.Frontiers in immunology,5, 417. Esparza, J. (2013). A brief history of the global effort to develop a preventive HIV vaccine.Vaccine,31(35), 3502-3518. Fauci, A. S., Folkers, G. K., Marston, H. D. (2014). Ending the global HIV/AIDS pandemic: the critical role of an HIV vaccine.Clinical Infectious Diseases,59(suppl 2), S80-S84. Haynes, B. F., McElrath, M. J. (2013). Progress in HIV-1 vaccine development.Current opinion in HIV and AIDS,8(4), 326. Haynes, B. F., Moody, M. A., Alam, M., Bonsignori, M., Verkoczy, L., Ferrari, G., ... Kelsoe, G. (2014). Progress in HIV-1 vaccine development.Journal of Allergy and Clinical Immunology,134(1), 3-10. Kim, J. H., Excler, J. L., Michael, N. L. (2015). Lessons from the RV144 Thai phase III HIV-1 vaccine trial and the search for correlates of protection.Annual review of medicine,66, 423-437. Koff, W. C. (2012). HIV vaccine development: challenges and opportunities towards solving the HIV vaccine-neutralizing antibody problem.Vaccine,30(29), 4310-4315. Kwong, P. D., Mascola, J. R., Nabel, G. J. (2012). The changing face of HIV vaccine research.Journal of the International AIDS Society,15(2). Martin, A. R., Siliciano, R. F. (2016). Progress toward HIV eradication: case reports, current efforts, and the challenges associated with cure.Annual review of medicine,67, 215-228. Russell, N. D., Marovich, M. A. (2016). Pox-Protein Public Private Partnership program and upcoming HIV vaccine efficacy trials.Current Opinion in HIV and AIDS,11(6), 614-619. Streeck, H., D'Souza, M. P., Littman, D. R., Crotty, S. (2013). Harnessing CD4+ T cell responses in HIV vaccine development.Nature medicine,19(2), 143-149. Watkins, D. I. (2012). Update on progress in HIV vaccine development.Top Antivir Med,20(2), 30-1.

Sunday, May 3, 2020

Understanding Crime in Canada

Question: What are the main methods (or tools) that criminologists use to measure crime rates and crime trends? Are crime rates trending upwards, downwards or staying about the same? Which crime categories (if any) are experiencing declines, which crime categories (if any) are experiencing increases, and which are staying about the same? Do the different types of measurement tools provide the same picture of crime rates and crime trends, or are the pictures different, and if so, why? Which crime measurement tool do you think is most reliable, and why? Answer: Like many other developed countries, in Canada also, the crime is measured with the help of a combination of the information provided by the police and reported by the victim. Although, individually each of these sources has its own strengths and limitations but together they are able to provide a much robust measure of crime rate and trends in Canada (Walker, 1999). There are a wide range of measurements used by the criminologists in order to examine statistics related with crime. In case of each of these tools, the respective measurements are derived from different aggregations of the data related with crime. The result is that in several cases, the crime rate in Canada is depicted in a way that is quite opposite to the objective reality. It also needs to be noted in this regard that the crime trends are not static entity and therefore they undergo considerable changes as a result of several social, political and economic factors (Boyd, 2015). There are certain methods that are generally used by the criminologists in order to measure the rate of crime and the trends related with crime. These main methods are the Uniform Crime Report, Crime Severity Investigation and General Social Survey. For example the Uniform Crime Report presents the uniform crime reporting statistics. In case of UCR, all aggregated data is collected. Moreover, UCR is incidence based. However there is a problem related with the UCR. According to this issue, UCR is not capable of accounting for the dark figures of crime. The dark figures of crime are related with the variations that are present between the number of crimes that have taken place and the crimes that have been reported to the authorities. In this way, this figure shows the large number of crimes that have not been reported (Fox, ed. 1981). On the other hand, the General Social Survey is conducted over the telephone. In this survey, questions related with crime or victimization is asked fro m the individuals that have not been reported in the Uniform Crime reports. These crimes include the cases of assault, robbery and sexual assault. In case of the Criminal Severity Index, each crime is measured according to its severity. At the same time, the severity of a crime is also determined on the basis of the sentence pronounced in the case (Kempf, 1990). Canada is facing the problem of high rate of crime. Although, generally the crime rate is going down but there are certain areas in which this rate is increasing. For example, recent trends revealed that there is an increase in violent crimes. On the other hand, the crimes like vehicle theft are witnessing a downward trend, perhaps due to the mandatory measures introduced by the government. In the same way, the recent trends revealed that there has been a decrease in the number of homicides but at the same time, there has been an increase in the cases of assault. Some factors can be cited in support of the decreasing rate of these crimes. For example, significant improvements have been made in emergency medical care. At the same time, the young people have become more risk tolerant. Similarly, as a result of the Internet, young people stay at home more often instead of going out. On the other hand, the rising popularity of Internet has also resulted in the crimes that take place on t he Internet itself (Jones, 2006). It is widely knowledge that the same results are not provided by different types of measurement tools when it comes to the crime rates and trends. The reason is that all these tools measure different things. For example, the Uniform Crime Report is based on the statistics of crime that are available with the police. Therefore the crime rate and trends depicted by the UCR also reflect the attitude and the opinions of the police officers and the policies and procedures adopted by them. For example, sometimes the police officers do not report significant instances of crime if they are capable of dealing with such instances effectively. On the other hand, this problem is effectively dealt with by victimization surveys as these surveys report the crimes in which the police is not involved. At this point, it needs to be noted that a large number of crimes are not reported to the police. In this way these surveys help in providing the vital information related with crime. But at the same ti me, there is also a problem associated with the service because in case of many crimes that have not been reported to the police, the people do not report these crimes during the survey conducted on the telephone (Maxfield, 1995). On the basis of the above discussion, it can be said that the most efficient crime measurement tool which is also the most reliable should have the features of Uniform Crime Report and also that of the General Social Survey. At the same time it is very important that the measurements of crime should include the crimes that have been reported as well as the crimes that have not been reported to the police (Burgess and Akers, 1966). In this way, instead of having different measurements for the crime rate and friends, the focus should be on including everything in a single measurement. It also needs to be noted in this regard that the statistics reported by the police and the victimization data are complementary to each other and if these two sources are used jointly, they can provide a more comprehensive picture of the crime rate and trends in Canada. As a result of the differences that are present in the methodology used by these two types of surveys, it is difficult to make a direct comparison. But it can certainly be said that the ways in which crime is measured in Canada can be improved further. By improving the tools that are used for measuring crime in Canada, the understanding regarding the nature and the extent of crime will also improve (Sampson, Groves and Byron, 1989). With the help of these improvements, and also by including Crime Severity Index to the present measurement tools, it is possible to have a more comprehensive picture regarding the nature and extent of crime in Canada. References Burgess, Robert and Akers, Ronald, 1966, "A Differential Association-Reinforcement Theory of Criminal Behavior" Social Problems, Vol. 14, No. 2, pp.128147 Fox, James A., ed. 1981, Methods In Quantitative Criminology. New York: Academic Press Jones, Stephen, 2006, Criminology. New York: Oxford University Press, USA Kempf, Kimberly, 1990, Measurement Issues in Criminology, New York: Springer Maxfield, Michael G. 1995, Research Methods for Criminal Justice and Criminology. Ed. Earl Babbie. California: Wadsworth Publishing Company Neil Boyd, (2015) Understanding Crime in Canada: An Introduction to Criminology, Emond Montgomery Publications Neuman, Lawrence W., and Bruce Wiegand, 2000, Criminal Justice Research Methods, Allyn and Bacon Sampson; Robert J. Groves, W. Byron, 1989, The American Journal of Sociology, Vol. 94, No. 4. pp.774802 Walker, Jeffrey T. 1999, Statistics In Criminal Justice: Analysis and Interpretation. Maryland: Aspen Publishers, Inc.